Simplified Chinese
If hepatitis B antibodies have disappeared, what is the most effective way to receive a booster vaccination?
Release date:
2024-04-10
Author:
Source:
Abstract
Since hepatitis B antibodies do not provide lifelong protection, even after receiving the hepatitis B vaccine, it is important to receive booster doses at regular intervals to maintain immunity.
Which populations are most in need of booster vaccinations?
Practice has shown that, after the first dose of 3 After receiving the hepatitis B vaccine, not everyone will develop antibodies; some individuals either fail to produce antibodies or generate antibody levels below 10 mIU/mL (where IU stands for international unit). We refer to this as non‑response, and such individuals account for approximately 5% of the entire vaccinated population. ~ 10% Left or right; if the antibody level is 10 ~100 mIU/ml Between these levels, we refer to it as a low response; only when the antibody level exceeds 100 mIU/mL. Only then can we refer to it as an effective or normal response. If an individual fails to respond or exhibits a low response after receiving the hepatitis B vaccine, they either lack protection against hepatitis B virus infection or develop antibodies that persist for only a short period, quickly losing their protective effect. For such individuals, a single booster dose of the hepatitis B vaccine will typically elicit sufficient antibody levels and establish immunological memory. Therefore, those who were non‑responders or low responders after their initial vaccination should undergo regular testing of the hepatitis B five‑marker panel; if antibodies have waned, timely booster immunization is essential.
In addition, individuals who frequently come into contact with hepatitis B patients or those who are positive for the hepatitis B surface antigen—such as patients requiring dialysis and people who use illicit drugs—are at a significantly higher risk of infection than the general population. For this reason, they are classified as high-risk groups for hepatitis B. After receiving the hepatitis B vaccine, these individuals tend to have shorter-lasting antibody persistence and are more likely to lose immune memory. Therefore, once antibodies in their bodies have waned, they should promptly receive booster doses of the hepatitis B vaccine to prevent infection.
Which vaccine provides the strongest immune protection?
Once antibodies have waned, if you wish to receive another dose of the vaccine, you should go to a qualified vaccination site—such as your local Center for Disease Control and Prevention, community health service center, or township health clinic. Additionally, some provinces and cities have established vaccination clinics at certain local hospitals to administer specific vaccines.
What kind of vaccine should be administered to achieve a booster effect?
This starts with the hepatitis B vaccine we receive. Typically, individuals under the age of 16… Children aged one year should receive a 10-μg dose of hepatitis B vaccine; adults aged 16 years or older should receive either a 20-μg or a 60-μg dose. In particular, for the aforementioned individuals who are non‑responders or low responders, or who belong to high‑risk groups for hepatitis B, those aged 16 years or older are best advised to receive a booster dose of the 60-μg formulation. This is currently the only high‑dose hepatitis B vaccine available worldwide, and a single dose can achieve an immune response comparable to that obtained with the standard three‑dose schedule of other vaccines. There is no need to worry about suboptimal vaccination outcomes due to missed doses resulting from a prolonged immunization schedule.
(This article is authored by Li Huayu, who holds a master’s degree in epidemiology and health statistics and previously served at the Disease Prevention and Control Center of a unit under the General Equipment Department of the People’s Liberation Army.)
Recommended Reading
Batch Release Status of the Company’s Products in 2026
2026-07-23
2026-07-15
2026-07-09
Contact Information
Customer Service Hotline
4001899806
Phone number
010-59613600
Official Website
Company Address
No. 35 Simiao Road and No. 25 Tianfu Street, Daxing Biomedical Industry Base, Zhongguancun Science Park, Daxing District, Beijing
WeChat Official Account